Anastrozole – An Anti-Breast Cancer Medication has a relatively lengthy elimination half-life of around 50 hours in postmenopausal women. This indicates that it takes around 50 hours for half of the medication to be eliminated from the body following the final dose. After approximately 7 days of once-daily dosage, anastrozole concentrations in the bloodstream are 3-4 times greater than after a single dose. A drug's full elimination requires numerous half-lives. Anastrozole is largely removed in the liver (approximately 85% of the dosage), with the remaining amount excreted unaltered in the urine (11%). The main circulating metabolite, triazole, has no pharmacological effect. While the exact duration for full elimination varies, anastrozole levels in the body remain high for a prolonged period after therapy is discontinued. Patients should discuss any concerns they have concerning anastrozole clearance with their physician.
