When it comes to fighting wrinkles, few skincare ingredients have earned the scientific respect that Tretinoin has. It’s often referred to as the “gold standard” in anti-aging and acne treatment for a reason. But if you’ve ever tried to get your hands on it, especially in the United States, you may have realized it’s not available over the counter (OTC) like other retinol-based products. This raises the question: Can you get Tretinoin without a prescription? And what’s the truth about all these so-called “Tretinoin over-the-counter creams” being sold online or internationally? Let’s break it down, myth-bust the confusion, and give you a research-backed guide to navigating your anti-aging skincare journey.